When a iodides in the follicle epithelial cells of the thyroid gland the iodine ions under the influence of the enzyme peroxidase oxidize iodide to form elemental iodine, which is incorporated into the molecule of tyrosine. Thus one part of tyrosine radicals iodized thyroglobulin, thereby forming thyronine, the main ones are thyroxine (T4) and buy sustaplex 250 triiodothyronine (T3). Thyronine form a complex with the protein thyroglobulin, which is deposited in the colloid of thyroid follicle. Iodine enters the body under physiological quantities prevents the development of endemic goitre (associated with iodine deficiency in the diet); normalizes thyroid size in infants, children and adolescents; and also affects the performance ratio T3/T4 , the level of thyroid-stimulating hormone.
- prevention of endemic goiter;
- goitre prevention of relapse after surgical removal;
- treatment of diffuse euthyroid goiter in infants, children, adolescents and young adults patients.
- pronounced thyrotoxicosis;
- thyrotoxicosis hidden (at doses exceeding 150 mg per day);
- dermatitis herpetiformis;
- toxic adenoma, nodular goiter when used in doses of 300 mg / day (except for pre-blockade therapy to thyroid);
- increased sensitivity to iodine.
Mikroyodid should not be taken with hypothyroidism, except in cases where the development of the latter is caused by severe iodine deficiency.
The appointments of the drug should be avoided during treatment with radioactive iodine, the presence or suspected thyroid cancer.
Dosing and Administration Prevention of endemic goiter : Babies and children : 50-100 micrograms of iodine per day. Teenagers and adults :. 100-200 micrograms of iodine per buy sustanon 250 day during pregnancy and lactation : 150-200 micrograms of iodine per day Preventing relapse after goitre surgical removal : 100 -200 micrograms of iodine daily Treatment of euthyroid goiter : Newborns, children and adolescents : 100-200 micrograms of iodine per day. Adult patients younger :. 300-500 micrograms of iodine per day The daily dose should be taken at once, . after eating, drinking plenty of fluids duration of intake Mikroyodida determined by your doctor. Use of the drug as a prophylactic measure is carried out for, usually several months or years, and often -. lifelong in children and adolescents a course usually require treatment of 6 up to 12 months.
When buy sustanon 250 using Mikroyodida on indications in the recommended doses, the occurrence of side effects is unlikely.
With long-term appointment of high doses (more than 300 mg / day) may develop iodine-induced hyperthyroidism (especially in elderly patients, in the presence of nodular goiter or toxic adenoma).
When therapy with high doses of iodine (more than 1 mg / day) in some cases can develop goiter and hypothyroidism caused by iodine.
Sometimes develop allergic reactions: rarely – hypersensitivity reactions in combination with the “iodine” rhinitis; yododerma, exfoliative dermatitis, angioedema. In rare cases, chronic administration of the drug can lead to the development of “yodizma” which can manifest metallic taste in the mouth, swelling and inflammation of the mucous membranes (rhinitis, conjunctivitis, bronchitis), fever iodine, an iodine acne, swelling of the salivary glands.
Interaction with other medicinal products
Treatment efficacy tireostatikami while taking iodine is reduced. Potassium perchlorate and thiocyanate inhibit the absorption of iodine by the thyroid gland. Thyroid-stimulating hormone improves the absorption of iodine by the thyroid gland and stimulates the production of its hormones.
Acceptance of high iodine doses and co-administration of potassium-sparing diuretics may lead to the development of hyperkalemia.
Co-administration therapy with high doses of iodine and lithium drugs contributes to the development of hypothyroidism and goiter.
Use during pregnancy and breast-feeding
during pregnancy and lactation increases the need for iodine. Mikroyodid designate indication in cases where dietary intake of iodine is less than 150-300 mg / day. The drug was well cross the placenta and can cause the development of hypothyroidism and goiter in the fetus. Iodine is also excreted in breast milk. Therefore, during pregnancy and breast-feeding drug should only be used at the recommended doses.