Bifonazole well into the affected skin layers. After 6 hours after application of different concentrations of the skin layers reach 1000 mg / cm 3 in the upper layer of the epidermis (stratum corneum) to 5 g / cm 3 in the papillary layer. Thus, all concentrations are obtained within the range of antifungal activity.
When applied to unbroken skin is absorbed bifonazole small amount (0.6-0.8% of the dose); bifonazole concentration levels in plasma while always below the detection limit (i.e. <1 ng / ml). Negligible absorbance sustanon 300 is detected only after the application of the solution on bifonazole inflamed skin (2 – 4% of the dose). Thus, as bifonazole are very low concentration when applied topically (typically less than 5 ng / ml) in the blood plasma, no systemic effects are observed. The duration of stay in the skin (for certain protective action against fungal infections in guinea pigs) – 36 -. 48 hours bifonazole crosses the placental barrier in rats.
Fungal diseases of the skin caused by dermatophytes, yeast, fungi, and Malassezia furfur and Corynebacterium minutissimum:
- tinea pedis (tinea foot skin and interdigital tinea pedis)
- mycoses of the hands (tinea skin of hands and interdigital tinea)
- tinea smooth body skin
- tinea groin
- superficial skin candidiasis
: Hypersensitivity to bifonazole or any other component of the formulation.
during pregnancy and lactation (see. “Use during pregnancy and lactation” section)
Children’s age (see. “The use in pediatric practice” section).
Use during pregnancy and lactation Pregnancy Absorption bifonazole with topical medication is negligible (see. Section “Pharmacokinetics”), These studies show that bifonazole does not appear to have any adverse effect on the mother and fetus. However, use of the drug during this period may, if the potential benefit to the mother outweighs the potential risk to the fetus or child. Lactation It is unknown whether bifonazole passes into breast milk in women. Bifonazole absorption with topical medication is negligible (see. “Pharmacokinetics” section). However, use of the drug during this period is possible if outweighs the potential risk to the fetus or child’s potential benefit to the mother. In appointing “Mikospor cream ® during the lactation period should avoid applying the cream on sustanon 300 the chest. Fertility The safety data obtained from preclinical studies give grounds It suggests that the use of bifonazole not exert any negative influence on the male and female fertility.
Use in pediatric patients
Specific studies in children have been conducted. Based on a review of clinical data did not reveal evidence of adverse side effects when using the drug in children. However, in children younger than 1 year Mikospor ® Cream should be used only under medical supervision.
Dosage and administration:
Outwardly, the solution is applied with a thin layer to the affected skin 1 time a day, preferably at night, and rub gently.
In order to achieve a satisfactory result, treatment should be continuous. Duration of therapy is usually:
- with athlete’s foot (tinea foot skin and interdigital tinea pedis): 3 weeks
- with mycosis of the hands (tinea skin of hands and interdigital tinea), body skin (tinea smooth skin) and skin folds (groin tinea): 2-3 weeks
- with pityriasis versicolor, erythrasma: 2 weeks
- when the surface of the skin candidiasis: 2-4 weeks.
For surface treatment of approximately palm area, quite a few drops of a solution (about 3 drops).
General disorders and local reactions: pain at the site of application, peripheral edema (at the site of application).
Infringements of the skin and subcutaneous tissue disorders: contact dermatitis, allergic dermatitis, erythema, pruritus, rash, hives, blisters, peeling and dryness of the skin, eczema, skin irritation, maceration, skin burning feeling. Side effects are reversible and disappear after discontinuation of the drug.
Interaction with other drugs
Absorption bifonazole with topical medication is negligible. Cases of interactions with other sustanon 300 drugs are unknown.
Special instructions .
Use with caution in patients with hypersensitivity to other antifungal medicines from the group of imidazole derivatives (econazole, clotrimazole, miconazole). Avoid contact with eyes solution.
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