The preparation contains natural enzymes from the pancreas of animals – protease, lipase and amylase, providing digestion of protein, fat and carbohydrate foods.
After receiving sustanon 250 cycle ® capsule quickly dissolves in the stomach, releasing the enteric coated pancreatin micropellets. Due to the small size, microgranules rapidly and uniformly mixed with the food and simultaneously bolus easily penetrate into the duodenum and then to small intestine, the pancreatic enzymes which are released and start to operate actively, contributing to the rapid and complete digestion of proteins, fats and carbohydrate food.
Rapid mixing microgranules of pancreatin with the contents of the stomach, their uniform distribution in it, the simultaneous passage with chyme and safety of enzymes before they start working in the intestine (due to enteric coating microgranules), provide a higher digestive activity and the maximum approximation of the drug to the natural process digestion. Enzymatic activity Mikrazima ® exercise maximum 30 minutes after ingestion, which provides fast onset of effect.
After reaction with substrates protease, lipase and amylase in the lower intestine and lose activity with intestinal contents excreted.
Mikrazim ® is not absorbed from the gastrointestinal tract and acts only in the intestinal lumen.
Substitution treatment for exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, post-irradiation, indigestion, cystic fibrosis; flatulence, diarrhea non-infectious origin.
Violation of digestion (a condition after resection of the stomach and small intestine) to improve food digestion in patients with normal function of the gastrointestinal tract in the case of errors in the diet (eating fatty foods, large quantities of food, irregular meals), and in violation of chewing function, sedentary lifestyle, prolonged immobilization. Remhelda Syndrome (gastrocardiac syndrome).
Preparing to X-ray examination and ultrasound of the abdomen.
Individual intolerance to pancreatin or the individual components of the preparation. Acute pancreatitis, exacerbation of chronic pancreatitis.
Use during pregnancy and lactation
Data on the potential risks of using pancreatin during pregnancy and lactation are not available, so the drug should be administered to pregnant and breastfeeding women only if the expected effect of therapy exceeds potential risks.
Information on the possible impact of the drug on the ability to drive vehicles, machinery Separate data are not available
Dosing and Administration
Dose selected individually depending on the age, degree of symptoms and diet composition. Dose selection is carried out using medicines registered Mikrazim ® 10,000 units and Mikrazim ® 25,000 units.The capsules are taken orally, drinking plenty of non-alkaline liquid (water, fruit juices). If a single dose of the drug is greater than 1 capsule sustanon 250 cycle to be taken half of the total number of capsules immediately before a meal, and the other half – during the meal. If a single dose – 1 capsule, it should be taken during meals. When difficulty in swallowing (eg in children or the elderly), the capsule can be opened and take the drug directly to the microgranules, pre-mixing them with liquids or liquid foods (pH <5.0), which does not require chewing (applesauce, yogurt). Grinding or chewing microgranules, and adding them to foods with a pH above 5.5 leads to the destruction of their shell, protecting from the action of gastric juice. Any mixture of microgranules with food or liquid should be taken immediately after preparation.
Permissible dose for children under the age of 1.5 years – 50 000 IU / day .; over 1.5 years – 100 000 IU / day.
The duration of the pancreatin may vary from a few days (indigestion) to several months or years (long-term replacement therapy).
Substitution therapy for various types of exocrine pancreatic insufficiency.
The dose is adjusted individually and depends on the severity of exocrine insufficiency, individual dietary habits and the age of the patient. Steatorrhea (more than 15 grams of fat in the stools per day). If you have diarrhea, weight loss and no effect of diet prescribed 25,000 units of lipase at every meal. If necessary, and good endurance increase the dose to 30 000 – 35 000 units of lipase at a time. Further increase of the dose, in most cases, does not improve the results of treatment and requires a review of the diagnosis, reduce the fat content in the diet and / or additional prescribing -. Proton pump inhibitorswith mild severe steatorrhoea, not accompanied by diarrhea and weight loss, appointed from 10 000 . U to 25 000 units of lipase at the reception . Cystic fibrosis Initial estimated dose for children under 4 years – 1 000 units of lipase per kilogram of body weight at each feeding for children over 4 years old – 500 units of lipase per kilogram of body weight at each meal. The dose should be selected individually, depending on the severity of the disease, the severity of steatorrhea and nutritional status. The maintenance dose for most patients should not exceed 10,000 units lipase per kilogram of body weight per day.
Allergic reactions to components of the preparation. When using high doses are rarely observed: diarrhea, nausea, constipation, discomfort in the epigastric region. With prolonged use at high doses may develop hyperuricosuria, hyperuricemia.
Symptoms: increased levels of uric acid in the urine (giperurikuriya) and blood (hyperuricemia). The children – constipation.
Treatment: removal of the drug, symptomatic therapy.
Interactions with other drugs With simultaneous application of pancreatin with iron preparations may decrease the absorption of the latter.
special sustanon 250 cycle instructions
. Children and adults receiving long-term therapy pancreatin in large doses, should be monitored by a specialist
The main reasons for the ineffectiveness of the enzyme therapy are: inactivation of enzymes in the duodenum as a result of acidification of the contents; related small bowel disease (worm infestation, dysbiosis); failure to comply with the recommended treatment regimen of patients; the use of enzymes that have lost their activity.