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Terbinafine specifically alters the early stage of the biosynthesis of sterols, occurring in fungi. This leads to a deficiency zrgosterola and to intracellular accumulation sustanon that causes the death of fungal cells. Terbinafine action effected by inhibition of the enzyme squalene epoxidase. located on the cell membrane of the fungus.

Terbinafine has no effect on the cytochrome P450 system in humans and, therefore, the metabolism of hormones or other drugs.

Pharmacokinetics. For external use absorption – less than 5%, has little systemic effect.

Indications. Prevention and treatment of fungal infections of the skin, including foot mycoses ( “mushroom” of the foot), jock itch (tinea cruris), fungal lesions of the smooth skin of the body (tinea corporis), caused by such dermatophytes as by Trichophyton (including , T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophytonfloccosum.

Yeast infections of the skin, mainly those caused genus Candida (e.g., Candida albicans), in particular diaper rash.

Colorful lichen {Pityriasis versicolor), called Pityrosporum orbiculare (also known as Malassezia furfur).

Contraindications. Hypersensitivity to terbinafine or any of the inactive ingredients included in the formulation.

Precautions: hepatic and / or renal failure, alcoholism, depression of bone marrow hematopoiesis, tumors, metabolic diseases, limb occlusive vascular disease, children under 12 years of age (lack of sufficient clinical experience).

Pregnancy and lactation. It was not teratogenic in experimental studies of the properties of terbinafine found. So far no reports of any malformation when applying Mikonorma. However, as clinical experience with terbinafine in pregnant women is very limited, it should be used only on strict conditions.

Terbinafine is excreted in breast milk. However, in the case of nursing mother Mikonorma cream it is absorbed through the skin a small amount of the active substance, so an adverse effect on the infant is unlikely.

Dosage and administration. Outwardly.

Adults and children 12 years of age: should be clean and dry the affected area before applying the cream. The cream is applied once or twice a day in a thin layer to the affected and surrounding skin areas and lightly rubbed. For infections involving intertrigo (under the breasts, in the interdigital spaces, between the buttocks, groin), cream application site can cover the gauze, especially at night. It is recommended to apply the cream in tubes With extensive fungal lesions of the body of 30 g

The average duration of treatment:
Tinea torso, legs: 1 week 1 time per day
Tinea pedis: 1 week 1 time per day
Skin Candidiasis: 1-2 weeks 1 or 2 times a day,
colorful versicolor: 2 weeks 1 or 2 times a day

Reducing the severity of clinical sustanon manifestations are usually noted in the first days of treatment. In the case of irregular or premature treatment termination there is a risk of renewed infection. If after one or two weeks of treatment were observed signs of improvement, there should be verification of the diagnosis.

cream Mikonorma Dosage in the elderly is not different from the above.

Use of the drug in children. We do not recommend the use of this drug in children under 12 years old.

Side effects. In the field application of the drug can be redness, itching or burning. Allergic reactions.

Overdose. No cases of overdose have been reported. If accidentally Mikonorm cream is ingested, it is possible to expect development of the same side effects as an overdose of tablets Terbinafine (headache, nausea, epigastric pain and dizziness).

Treatment: activated charcoal, if necessary – symptomatic supportive therapy.

Interactions. There are no drug interactions are not known for Mikonorma cream.

Special instructions. Reducing the severity of clinical manifestations are usually noted in the first days of treatment. In the case of irregular or premature treatment termination there is a risk of recurrence of infection.

Mikonorm Cream is for external use only. Avoid getting it in your eyes, as it may cause irritation. In case of accidental contact with the drug in the eyes, they should immediately wash with running water, and in the case of persistent phenomena of irritation consult a doctor. With the development of allergic reactions need to stop sustanon the drug.

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